Case 6: A 44 year old male with HIV presents with a headache

Written by 
Mohammed H Mohammed, MD. Chief Resident, Department of Medicine, Wayne State University, Detroit, MI, USA 
Reviewed by
Zahir Osman Eltahir Babiker, MRCP, MSc, DLSHTM, DTM&H. Specialist Registrar in Infectious Diseases & Virology, Manchester, UK
 

History:

A 44 year old male with advanced HIV/AIDS (CD4 count of 4 cells/micro liter 2 months prior to admission) not on HAART (Highly Active Antiretroviral therapy) presented to the Emergency Department complaining of a headache for the last 14 days. He also complained of intolerance to light and neck stiffness. He vomited 3 times over the last 3 days. He denied any fever or night sweats. No hematemesis.

Past Medical History: HIV diagnosed 8 years prior to admission. 

Social History: Smokes one pack per day for the last 30 years. No history of intravenous drug abuse. He had acquired HIV through female sexual contact.

Family History: Father had MI at the age of 62.

Drug History: None

Review of Systems: Photophobia, phonophobia, Poor appetite with 10 pounds (4.5 kilograms) weight loss in the last 3 months. Cough productive of yellowish sputum for the last 2 weeks.

Physical Examination:

Pulse Rate: 77/min, Temperature: 35 degrees celsius.  Respiratory Rate: 20 breaths/min.  

Blood Pressure: 112/83.  Oxygen Saturation: 100% on Room Air

GENERAL: The patient appeared very cachectic with significant temporal wasting.  He appeared in moderate distress especially with the lights on.

HEENT (Head, Eyes, Ear, Nose, throat examination): Pupils equal, round, reactive to light.  Extraocular movements intact.  Mild conjunctival pallor. No papilledema on funduscopic examination. Poor dentition. Moist mucous membrane. No oral ulcers. Non-scrapable white plaques were present on the left lateral tongue border.

NECK:  His neck was stiff.

LUNGS:  Symmetric chest expansion, clear to auscultation bilaterally.  No crackles or wheezes heard.  No dullness to percussion.  No egophony appreciated.

Cardiovascular:  S1, S2 present.  Regular rate and rhythm.  No murmurs, rub, or gallop.  JVP was not elevated. No carotid bruit. Peripheral pulses palpable.

ABDOMEN:  Soft, neither tender nor distended.  No guarding.  Bowel sounds heard in all quadrants. No organomegaly appreciated.

NEUROLOGICAL EXAMINATION:  Confused and lethargic.  Cranial nerves II through XII grossly intact.  Strength 5/5 in all limbs. Kernig’s sign was positive but Brudzinski’s negative.

BACK/EXTREMITIES:  No spinal tenderness.  No CVA (costovertebral angle) tenderness.  No skin lesions seen.  No pedal edema. Dorsalis pedis and posterior tibial arteries scored 2+ bilaterally.

GENITALIA/RECTAL:  Normal male genitalia.  No lesions noted. 

  1. Question 1: What is the next best step?
 

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